Zolotykh M A
Urologiia. 2007 Nov-Dec(6):31-6.
The activity of lactate dehydrogenase (LDG), malate dehydrogenase (MDG), concentrations of lactic acid and lipid peroxidation (LPO) products in the blood serum and urine were estimated in 119 patients with acute pyelonephritis (70 cases of serous and 49 cases of purulent). The results of the study showed that acute pyelonephritis patients have activated anaerobic glycolysis. Ischemia leads to accumulation of lactic acid, activation of LPO. Significant differences between the groups of patients reflect strong influence of renaltissue ischemia on activity of systemic metabolic processes and metabolism in renal parenchyma. Standard infusion therapy was given to 30 patients with acute purulent pyelonephritis. 19 patients received solution of succinic acid reamberin. On day 4 of reamberin therapy plasma and urine activity of LDG and MDG attenuated, lactic acid concentration decreased, content of dienic conjugates was close to normal. Patients on reamberin treatment exhibited earlier relief of endogenic intoxication and improvement of blood count. Thus, succinic acid drugs reduce renal ischemia, improve a course of postoperative period in patients with acute purulent pyelonephritis.
对119例急性肾盂肾炎患者（70例浆液性和49例脓性）的血清和尿液中的乳酸脱氢酶（LDG）、苹果酸脱氢酶（MDG）活性、乳酸浓度及脂质过氧化（LPO）产物进行了评估。研究结果表明，急性肾盂肾炎患者的无氧糖酵解被激活。缺血导致乳酸积累、LPO激活。患者组间的显著差异反映了肾组织缺血对全身代谢过程活性及肾实质代谢的强烈影响。对30例急性脓性肾盂肾炎患者进行了标准输液治疗。19例患者接受了琥珀酸雷美宁溶液治疗。在雷美宁治疗的第4天，血浆和尿液中LDG和MDG的活性减弱，乳酸浓度降低，二烯共轭物含量接近正常。接受雷美宁治疗的患者内源性中毒缓解较早，血细胞计数得到改善。因此，琥珀酸类药物可减轻肾脏缺血，改善急性脓性肾盂肾炎患者术后病程。
