Bucca S, Carli A, Buckley T, Dolci G, Fogarty U
Somerton Equine Hospital, Friarstown, Kildare, Co Kildare, Ireland.
Theriogenology. 2008 Oct 15;70(7):1093-100. doi: 10.1016/j.theriogenology.2008.06.029. Epub 2008 Jul 22.
The present study describes the effect of a single dose of dexamethasone administered to mares at time of breeding. In an initial experiment, the authors investigated safety of treatment. In a second experiment the effect of treatment on the uterine environment, fetal development and pregnancy outcome was examined. In the final part of the study, mares susceptible to persistent mating induced endometritis were identified, by means of a risk factor score system and the effect of treatment evaluated. Results indicated that dexamethasone administered at breeding time did not negatively impact on mares medical and reproductive traits. A reduced inflammatory response was observed post-mating in treated versus control mares and mares with multiple risk factors for susceptibility to persistent mating induced endometritis showed improved pregnancy rates following treatment. The authors concluded that a single dose of dexamethasone administered at the time of breeding is safe and can be used to modulate the uterine inflammatory response to breeding in susceptible mares.
本研究描述了在母马配种时给予单剂量地塞米松的效果。在初始实验中，作者研究了治疗的安全性。在第二个实验中，检测了治疗对子宫环境、胎儿发育和妊娠结局的影响。在研究的最后部分，通过风险因素评分系统识别出易患持续性交配诱发子宫内膜炎的母马，并评估了治疗效果。结果表明，配种时给予地塞米松对母马的医学和生殖特性没有负面影响。与对照母马相比，治疗后的母马在交配后炎症反应降低，并且具有多种持续性交配诱发子宫内膜炎易感性风险因素的母马在治疗后妊娠率有所提高。作者得出结论，配种时给予单剂量地塞米松是安全的，可用于调节易感母马对配种的子宫炎症反应。
