伊波加因，一种抗成瘾药物：药理学及进一步研发时机。一篇叙述性综述。

Ibogaine, an anti-addictive drug: pharmacology and time to go further in development. A narrative review.

作者信息

Maciulaitis R, Kontrimaviciute V, Bressolle F M M, Briedis V

机构信息

Department of Basic and Clinical Pharmacology, Kaunas University of Medicine, Lithuania.

出版信息

Hum Exp Toxicol. 2008 Mar;27(3):181-94. doi: 10.1177/0960327107087802.

DOI:10.1177/0960327107087802

PMID:18650249

Abstract

Ibogaine is an indole alkaloid derived from the bark of the root of the African shrub Tabernanthe iboga. Psychoactive properties of ibogaine have been known for decades. More recently, based on experimental data from animals and anectodal reports in human, it has been found that this drug has anti-addictive effects. Several patents were published between 1969 and 1995. The pharmacology of ibogaine is quite complex, affecting many different neurotransmitter systems simultaneously. However, the pharmacological targets underlying the physiological and psychological actions of ibogaine are not completely understood. Ibogaine is rapidly metabolized in the body in noribogaine. The purpose of this article was to review data from the literature concerning physicochemical properties, bio-analytical methods, and pharmacology of ibogaine; this article will be focused on the use of this drug as anti-addictive agent.

摘要

伊博格碱是一种从非洲灌木伊博格（Tabernanthe iboga）根部树皮中提取的吲哚生物碱。几十年来，人们一直知晓伊博格碱的精神活性特性。最近，基于动物实验数据和人类的轶事报告，发现这种药物具有抗成瘾作用。1969年至1995年间发表了几项专利。伊博格碱的药理学相当复杂，会同时影响许多不同的神经递质系统。然而，伊博格碱生理和心理作用背后的药理学靶点尚未完全明确。伊博格碱在体内会迅速代谢为去甲伊博格碱。本文的目的是综述文献中有关伊博格碱的物理化学性质、生物分析方法和药理学的数据；本文将重点关注这种药物作为抗成瘾剂的用途。