[伊波加因——治疗药物成瘾的物质。神经化学和药理作用]
[Ibogaine--the substance for treatment of toxicomania. Neurochemical and pharmacological action].
作者信息
Kazlauskas Saulius, Kontrimaviciūte Violeta, Sveikata Audrius
机构信息
Department of Analytical and Toxicological Chemistry, Kaunas University of Medicine, Kaunas, Lithuania.
出版信息
Medicina (Kaunas). 2004;40(3):216-9.
The review of scientific literature, concerning the indol alkaloid Ibogaine, which is extracted from the bush Tabernanthe Iboga, is presented in this article. Used as a stimulating factor for hundred of years in non-traditional medicine, this alkaloid could be important for modern pharmacology because of potential anti-addictive properties. The mechanism of action of this alkaloid is closely related to different neurotransmitting systems. Studies with animals allow concluding that Ibogaine or medicines based on this alkaloid can be used for treatment of drug dependencies.
本文介绍了有关从伊博格灌木中提取的吲哚生物碱伊波加因的科学文献综述。这种生物碱在非传统医学中作为刺激因子已使用了数百年，由于其潜在的抗成瘾特性，可能对现代药理学具有重要意义。这种生物碱的作用机制与不同的神经传递系统密切相关。对动物的研究表明，伊波加因或基于这种生物碱的药物可用于治疗药物依赖。
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