Potter G K, Strauss H, Potter R C
J Foot Surg. 1991 Mar-Apr;30(2):147-50.
Pedal metastases from visceral cancers, while rare, constitute a consideration in the presence of an otherwise unexplained mass in the skin, subcutis, or bones of the foot. Metastatic lesions may be presenting signs of visceral malignant tumors, or may remain occult for years after extirpation of the primary visceral lesion. The presented case depicts sudden activation and growth of an occult renal cell carcinoma metastasis in the subcutaneous tissue of a 69-year-old man's left fifth toe, 10 years after ipsilateral nephrectomy. Cytogenetic studies correlate with tumor histologic patterns and help to predict heritability, uni- or bilaterality, and local and systemic biologic behavior of renal cell carcinoma, thereby aiding in prognosis and treatment planning.
内脏癌的足部转移虽然罕见，但在足部皮肤、皮下组织或骨骼出现不明原因肿块时需要考虑。转移性病变可能是内脏恶性肿瘤的首发症状，也可能在原发性内脏病变切除后数年仍隐匿存在。本文报道的病例描述了一名69岁男性在同侧肾切除术后10年，左足第五趾皮下组织中隐匿性肾细胞癌转移灶突然激活并生长。细胞遗传学研究与肿瘤组织学模式相关，有助于预测肾细胞癌的遗传性、单侧或双侧性以及局部和全身生物学行为，从而辅助预后评估和治疗方案制定。
