Kaluzny Bartlomiej J, Szkulmowska Anna, Szkulmowski Maciej, Bajraszewski Tomasz, Wawrocka Anna, Krawczynski Maciej R, Kowalczyk Andrzej, Wojtkowski Maciej
Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Cornea. 2008 Aug;27(7):830-2. doi: 10.1097/ICO.0b013e31816be90f.
Spectral optical coherence tomography (SOCT) is a new imaging technique that can provide high-resolution tomograms much faster and with higher sensitivity than conventional Time domain (TdOCT) systems. Its usefulness in producing cross-sectional imaging of different corneal pathologies in vivo has already been presented. The aim of this case report is to show 830-nm SOCT findings in granular corneal dystrophy.
A 48-year-old woman with granular corneal dystrophy was examined with a slit-lamp, confocal microscope (Confoscan 4) and a prototype SOCT instrument constructed at the Institute of Physics, Nicolaus Copernicus University, Torun, Poland. A genetic examination showed a mutation of arginine 555-to-tryptophan (Arg555Trp) in the TGFBI gene that confirmed the clinical diagnosis.
SOCT tomograms showed multiple hyperreflective changes throughout the corneal stroma that corresponded to hyaline deposits. Precise and objective assessment of the localization, size, shape, and light scattering properties of the pathologic changes was possible. Three-dimensional rendering of the acquired data allowed a comprehensive evaluation of the deposits in the central cornea.
SOCT (830 nm) provides clinically valuable 2- and 3-dimensional assessments of pathomorphologic changes in granular corneal dystrophy in vivo.
光谱光学相干断层扫描（SOCT）是一种新的成像技术，与传统的时域光学相干断层扫描（TdOCT）系统相比，它能够更快且更灵敏地提供高分辨率断层图像。其在体内对不同角膜病变进行横断面成像的实用性已得到证实。本病例报告的目的是展示颗粒状角膜营养不良的830纳米SOCT检查结果。
对一名患有颗粒状角膜营养不良的48岁女性进行了裂隙灯、共焦显微镜（Confoscan 4）以及由波兰托伦哥白尼大学物理研究所构建的SOCT原型仪器检查。基因检测显示转化生长因子β诱导蛋白（TGFBI）基因中精氨酸555突变为色氨酸（Arg555Trp），这证实了临床诊断。
SOCT断层图像显示整个角膜基质有多处高反射变化，对应于透明样沉积物。对病变的定位、大小、形状和光散射特性进行精确且客观的评估是可行的。对采集数据进行三维重建可全面评估中央角膜的沉积物。
SOCT（830纳米）在体内对颗粒状角膜营养不良的病理形态学变化提供了具有临床价值的二维和三维评估。
