Mantovani Alberto, Allavena Paola, Sica Antonio, Balkwill Frances
Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, Italy.
Nature. 2008 Jul 24;454(7203):436-44. doi: 10.1038/nature07205.
The mediators and cellular effectors of inflammation are important constituents of the local environment of tumours. In some types of cancer, inflammatory conditions are present before a malignant change occurs. Conversely, in other types of cancer, an oncogenic change induces an inflammatory microenvironment that promotes the development of tumours. Regardless of its origin, 'smouldering' inflammation in the tumour microenvironment has many tumour-promoting effects. It aids in the proliferation and survival of malignant cells, promotes angiogenesis and metastasis, subverts adaptive immune responses, and alters responses to hormones and chemotherapeutic agents. The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
炎症的介质和细胞效应物是肿瘤局部微环境的重要组成部分。在某些类型的癌症中，炎症状态在恶性病变发生之前就已存在。相反，在其他类型的癌症中，致癌性改变会诱导促进肿瘤发展的炎症微环境。无论其起源如何，肿瘤微环境中“隐匿性”炎症具有多种促进肿瘤的作用。它有助于恶性细胞的增殖和存活，促进血管生成和转移，破坏适应性免疫反应，并改变对激素和化疗药物的反应。目前正在阐明这种与癌症相关炎症的分子途径，从而确定可能改善诊断和治疗的新靶分子。
