在实验性心肌炎的超急性期，QRS电压会短暂升高。
QRS voltages are transiently increased at the superacute stage of experimental myocarditis.
作者信息
Kishimoto Chiharu, Ohmae Minoru, Tomioka Nobuyoshi
机构信息
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto.
出版信息
Exp Clin Cardiol. 2008 Spring;13(1):15-8.
BACKGROUND
There are few reports on the precise electrocardiographic characteristics of acute myocarditis. The present study was focused on QRS voltage changes at the superacute stage of murine myocarditis.
METHODS
Serial electrocardiograms were recorded during the acute stage of viral myocarditis in mice, and then the cardiac pathology was examined. After recording baseline electrocardiograms, mice (n=235) were inoculated intraperitoneally with the encephalomyocarditis virus, resulting in severe myocarditis. Electrocardiograms were serially recorded until nine days after virus inoculation (superacute stage, days 3 to 6; acute stage, days 7 to 9). Changes in heart rate and QRS voltages were analyzed.
RESULTS
Serial electrocardiograms revealed that heart rates began to increase after day 3, and that the sum of the QRS voltages increased on day 3 and then decreased on days 7 to 9. Trivial mononuclear cell infiltrations and interstitial edema were most frequently found in mice at the superacute stage.
CONCLUSIONS
Transient increase of the QRS voltages at the superacute stage of myocarditis was demonstrated, which may be due to an increase in ventricular mass caused by interstitial edema at this stage.
背景
关于急性心肌炎精确心电图特征的报道较少。本研究聚焦于小鼠心肌炎超急性期的QRS波电压变化。
方法
在小鼠病毒性心肌炎急性期记录系列心电图，然后检查心脏病理学情况。记录基线心电图后，235只小鼠经腹腔接种脑心肌炎病毒，引发严重心肌炎。系列心电图记录至病毒接种后九天（超急性期，第3至6天；急性期，第7至9天）。分析心率和QRS波电压的变化。
结果
系列心电图显示，第3天后心率开始增加，QRS波电压总和在第3天增加，然后在第7至9天下降。在超急性期小鼠中最常发现轻微单核细胞浸润和间质水肿。
结论
证实了心肌炎超急性期QRS波电压短暂升高，这可能是由于该阶段间质水肿导致心室质量增加所致。
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