Kishimoto C, Matsumori A, Kawai C
Jpn Circ J. 1983 Nov;47(11):1317-21. doi: 10.1253/jcj.47.1317.
We studied serial electrocardiographic changes in murine myocarditis due to encephalomyocarditis (EMC) virus. After taking control electrocardiograms using standard extremity and 2 precordial leads, 86 mice were intraperitoneally inoculated with a 0.1 ml of the M variant of EMC virus suspension containing 100 TCID50. Electrocardiograms were recorded everyday from the 2nd to the 14th day, and thereafter once every 3-5 days until the 35th day. The cumulative incidence of myocarditis was 90% (77 out of 86). The control electrocardiogram showed a heart rate of 528 +/- 87 beats/min (mean +/- SD) and PR intervals of 0.03-0.05 sec, and significant rhythm or conduction disturbances were not found. Various electrocardiographic abnormalities, such as atrial (10%) and ventricular (21%) premature contractions, were noticed on the 4th to the 14th day. After 15-35 days arrhythmias still remained in 3 mice. The presence of arrhythmias in the chronic stage of myocarditis suggests that arrhythmias in some patients with no other clinical manifestations may be a sequela of the previous viral myocarditis. Thus, this study may contribute clinically to the clarification of the electrocardiographic characteristics in viral myocarditis.
我们研究了由脑心肌炎（EMC）病毒引起的小鼠心肌炎的系列心电图变化。使用标准肢体导联和2个胸前导联记录对照心电图后，86只小鼠腹腔注射0.1 ml含100 TCID50的EMC病毒M变异株悬液。从第2天至第14天每天记录心电图，此后每3 - 5天记录一次，直至第35天。心肌炎的累积发病率为90%（86只中有77只）。对照心电图显示心率为528±87次/分钟（平均值±标准差），PR间期为0.03 - 0.05秒，未发现明显的节律或传导紊乱。在第4天至第14天观察到各种心电图异常，如房性（10%）和室性（21%）早搏。15 - 35天后，3只小鼠仍存在心律失常。心肌炎慢性期心律失常的存在表明，一些无其他临床表现的患者的心律失常可能是先前病毒性心肌炎的后遗症。因此，本研究可能在临床上有助于阐明病毒性心肌炎的心电图特征。
