Marcotte Richard, Muller William J
Molecular Oncology Group, Royal Victoria Hospital, room H5.21, 687 Pine Avenue West, Montreal, QC, Canada H3A 1A1.
J Mammary Gland Biol Neoplasia. 2008 Sep;13(3):323-35. doi: 10.1007/s10911-008-9087-3. Epub 2008 Jul 24.
The advent of genetically engineered mouse models (GEMs) of human breast cancer, have provided important insight into molecular basis or human breast cancer. This review will focus on two of the most extensively studied mouse models for human breast cancer involving mammary gland specific expression of the polyoma middle T (PyV MT) antigen and of the ErbB2. In addition, this review will discuss past and recent advances in understanding relative contribution of the signaling pathways in tumor induction and metastasis by these potent mammary oncogenes.
人类乳腺癌基因工程小鼠模型（GEMs）的出现，为深入了解人类乳腺癌的分子基础提供了重要线索。本综述将聚焦于两种针对人类乳腺癌进行了广泛研究的小鼠模型，它们分别涉及多瘤病毒中间T（PyV MT）抗原和ErbB2在乳腺中的特异性表达。此外，本综述还将讨论在理解这些强大的乳腺癌基因在肿瘤诱导和转移中信号通路的相对作用方面过去和近期取得的进展。
