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构巢曲霉几丁质合酶在菌丝生长、分生孢子梗发育和隔膜形成中的功能多样性

Functional diversity of chitin synthases of Aspergillus nidulans in hyphal growth, conidiophore development and septum formation.

作者信息

Horiuchi Hiroyuki

机构信息

Department of Biotechnology, The University of Tokyo, Tokyo, Japan.

出版信息

Med Mycol. 2009;47 Suppl 1:S47-52. doi: 10.1080/13693780802213332. Epub 2008 Jul 14.

DOI:10.1080/13693780802213332
PMID:18651309
Abstract

Fungal chitin synthases are classified into seven classes. Recent advances in genome sequence analyses have revealed that there are more than seven chitin synthase-encoding genes in the genome of filamentous ascomycete fungi. To clarify the functional differences among these genes in the morphogenesis and hyphal tip growth, we have cloned six chitin synthase-encoding genes from Aspergillus nidulans and analyzed their functions. The results obtained suggest that chitin synthases are structurally and functionally divergent and play crucial roles in the growth and morphogenesis of A. nidulans.

摘要

真菌几丁质合成酶分为七类。基因组序列分析的最新进展表明，丝状子囊菌真菌的基因组中存在七个以上编码几丁质合成酶的基因。为了阐明这些基因在形态发生和菌丝顶端生长中的功能差异，我们从构巢曲霉中克隆了六个编码几丁质合成酶的基因并分析了它们的功能。所得结果表明，几丁质合成酶在结构和功能上存在差异，并且在构巢曲霉的生长和形态发生中起关键作用。

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