Ikeda T, Ochi H, Ohtani I, Fujiyama K, Hoshino T, Tanaka Y, Takeuchi T, Mashiba H
First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
J Intern Med. 1991 Aug;230(2):131-4. doi: 10.1111/j.1365-2796.1991.tb00420.x.
To determine the possible role of a glycaemic control in lipid metabolism in non-insulin-dependent diabetes mellitus (NIDDM) patients, serum lipid and apolipoprotein levels were measured in well-controlled and poorly controlled lean NIDDM without proteinuria and hypertension. A sample of 96 lean NIDDM patients (body mass index less than 25 kg m-2 in men and less than 27 kg m-2 in women) were divided into two groups: group I, where the HbA1c concentration had been less than 6% for the previous 3 months, and group II, where the HbA1c concentration had been greater than 8% for the previous 3 months. Serum total cholesterol, triglyceride, and HDL-cholesterol levels showed no significant differences between groups I and II. Furthermore, serum levels of apolipoproteins AI, AII, B, CII, CIII, and E did not differ significantly between groups I and II. These results suggest that glycaemic control did not influence lipid metabolism in lean NIDDM patients.
为了确定血糖控制在非胰岛素依赖型糖尿病（NIDDM）患者脂质代谢中可能发挥的作用，我们对无蛋白尿和高血压的血糖控制良好及控制不佳的瘦型NIDDM患者的血脂和载脂蛋白水平进行了测量。96例瘦型NIDDM患者（男性体重指数小于25 kg/m²，女性小于27 kg/m²）被分为两组：第一组，前3个月糖化血红蛋白（HbA1c）浓度低于6%；第二组，前3个月HbA1c浓度高于8%。第一组和第二组之间血清总胆固醇、甘油三酯和高密度脂蛋白胆固醇水平无显著差异。此外，第一组和第二组之间载脂蛋白AI、AII、B、CII、CIII和E的血清水平也无显著差异。这些结果表明，血糖控制对瘦型NIDDM患者的脂质代谢没有影响。
