Ikeda T, Ohtani I, Fujiyama K, Hoshino T, Tanaka Y, Tekeuchi T, Mashiba H
Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Diabete Metab. 1991 May-Jun;17(3):373-8.
To elucidate the changes of serum apolipoproteins as possible atherogenic factors in non-insulin-dependent diabetes mellitus (NIDDM), comparison was made between 47 NIDDM patients with clinical macroangiopathy (coronary heart disease and/or cerebral infarction) and 47 NIDDM patients without clinical macroangiopathy individually matched for age, sex, body mass index, glycemic control, mode of therapy, and blood pressure. Serum total cholesterol (223 +/- 63 mg/dl, mean +/- SD) and triglyceride (160 +/- 72 mg/dl) levels in NIDDM with clinical macroangiopathy were significantly higher than those (198 +/- 44 and 126 +/- 78 mg/dl) in control NIDDM. Apolipoprotein AII (apo AII) (28.8 +/- 6.9 mg/dl) in NIDDM with clinical macroangiopathy was significantly lower than that (31.4 +/- 5.5 mg/dl) in control NIDDM, and apo B (147 +/- 48 mg/dl) and apo CIII (13.1 +/- 5.9 mg/dl) in NIDDM with clinical macroangiopathy was significantly higher than that (113 +/- 35 and 10.8 +/- 4.7 mg/dl) in control NIDDM, respectively. There were no significant differences in apo AI, CII, and E levels. The ratio of HDL cholesterol to apo AI (0.36 +/- 0.08) and total cholesterol to apo B (1.6 +/- 0.3) in NIDDM with clinical macroangiopathy was significantly lower than that (0.40 +/- 0.09 and 1.8 +/- 0.4) in control NIDDM. These results suggest that abnormality of lipid metabolism is more significant in NIDDM with clinical macroangiopathy than in NIDDM without clinical macroangiopathy, and is more pronounced in women than in men.
为阐明血清载脂蛋白作为非胰岛素依赖型糖尿病（NIDDM）中可能的致动脉粥样硬化因素的变化，对47例患有临床大血管病变（冠心病和/或脑梗死）的NIDDM患者与47例无临床大血管病变的NIDDM患者进行了比较，后者在年龄、性别、体重指数、血糖控制、治疗方式和血压方面进行了个体匹配。患有临床大血管病变的NIDDM患者的血清总胆固醇（223±63mg/dl，均值±标准差）和甘油三酯（160±72mg/dl）水平显著高于对照NIDDM患者（198±44和126±78mg/dl）。患有临床大血管病变的NIDDM患者的载脂蛋白AII（apo AII）（28.8±6.9mg/dl）显著低于对照NIDDM患者（31.4±5.5mg/dl），而患有临床大血管病变的NIDDM患者的apo B（147±48mg/dl）和apo CIII（13.1±5.9mg/dl）分别显著高于对照NIDDM患者（113±35和10.8±4.7mg/dl）。apo AI、CII和E水平无显著差异。患有临床大血管病变的NIDDM患者中高密度脂蛋白胆固醇与apo AI的比值（0.36±0.08）和总胆固醇与apo B的比值（1.6±0.3）显著低于对照NIDDM患者（0.40±0.09和1.8±0.4）。这些结果表明，与无临床大血管病变的NIDDM相比，患有临床大血管病变的NIDDM患者的脂质代谢异常更显著，且在女性中比男性更明显。
