Gibb W R, Lees A J
King's College School of Medicine and Dentistry, London.
J Neurol Neurosurg Psychiatry. 1991 May;54(5):388-96. doi: 10.1136/jnnp.54.5.388.
In six control subjects pars compacta nerve cells in the ventrolateral substantia nigra had a lower melanin content than nerve cells in the dorsomedial region. This coincides with a natural anatomical division into ventral and dorsal tiers, which represent functionally distinct populations. In six cases of Parkinson's disease (PD) the ventral tier showed very few surviving nerve cells compared with preservation of cells in the dorsal tier. In 13 subjects without PD, but with nigral Lewy bodies and cell loss, the degenerative process started in the ventral tier, and spread to the dorsal tier. This pattern of selective degeneration of nigrostriatal neurons is not seen in ageing or after acute administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
在6名对照受试者中，腹外侧黑质致密部的神经细胞黑色素含量低于背内侧区域的神经细胞。这与自然的解剖学划分相吻合，即分为腹侧层和背侧层，它们代表功能不同的细胞群。在6例帕金森病（PD）患者中，与背侧层细胞得以保留相比，腹侧层存活的神经细胞极少。在13名无PD但有黑质路易小体和细胞丢失的受试者中，变性过程始于腹侧层，并蔓延至背侧层。这种黑质纹状体神经元的选择性变性模式在衰老过程中或急性给予MPTP（1-甲基-4-苯基-1,2,3,6-四氢吡啶）后未见。
