Mochizuki H, Imai H, Endo K, Yokomizo K, Murata Y, Hattori N, Mizuno Y
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Neurosci Lett. 1994 Feb 28;168(1-2):251-3. doi: 10.1016/0304-3940(94)90462-6.
The mechanism of abnormal iron accumulation in the substantia nigra (SN) pars compacta of patients with Parkinson's disease (PD) is unknown. To explore this question, we made a hemiparkinsonism model in monkeys by injecting 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the caudate or putamen on one side, and compared iron content in the SN and other basal ganglia structures by histochemistry. The injected side, especially the SN pars compacta, showed a marked increase in iron staining. Our study indicates that an injury to the nigrostriatal system by MPTP injection can induce iron accumulation in the SN.
帕金森病（PD）患者黑质致密部铁异常蓄积的机制尚不清楚。为探究这个问题，我们通过向一侧尾状核或壳核注射1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）制作了猴偏侧帕金森病模型，并通过组织化学比较黑质及其他基底神经节结构中的铁含量。注射侧，尤其是黑质致密部，铁染色显著增加。我们的研究表明，MPTP注射对黑质纹状体系统的损伤可诱导黑质中铁的蓄积。
