Spasov A A, Samokhina M P, Bulanov A E, Naumenko L V, Agarkov D Iu, Sorokina E V
Eksp Klin Farmakol. 2008 May-Jun;71(3):31-3.
Extracts of Gymnemy sylvestre (GS) exhibit hemorheological activity. The most pronounced effect was observed for GL extract in 25 wt % concentration, which (i) induced a decrease in the viscosity of blood and washed erythrocyte suspensions in the entire range of shear rates by a factor of 1,3 (ii) reduced the degree of deformability of red blood cells, (iii) increased the degree of osmotic resistance of erythrocytes by 21.3%, (iv) increased the intensity of fluorescence of DSM+ probe in erythrocyte suspensions by a factor of 1.5, and (v) decreased the degree of anisotropy, thus generally improving the viscoelastic properties of the erythrocyte membrane and preventing the thrombocyte aggregation. In this respect, the GS extract activity exceeded that of Tanakan.
匙羹藤提取物(GS)具有血液流变学活性。在25 wt%浓度下,GL提取物的效果最为显著,它(i)使血液和洗涤过的红细胞悬液在整个剪切速率范围内的粘度降低了1.3倍,(ii)降低了红细胞的变形程度,(iii)使红细胞的渗透压抗性程度提高了21.3%,(iv)使红细胞悬液中DSM+探针的荧光强度提高了1.5倍,以及(v)降低了各向异性程度,从而总体上改善了红细胞膜的粘弹性特性并防止血小板聚集。在这方面,GS提取物的活性超过了达纳康。