Soma P F, Chibbaro S, Makiese O, Marsella M, Diemidio P, Fricia M, Passanisi M, Catania V, Siragò P, Ventura F
Department of Plastic Surgery, University Hospital, Catania, Italy.
J Clin Neurosci. 2008 Sep;15(9):988-92. doi: 10.1016/j.jocn.2007.09.014. Epub 2008 Jul 23.
Malignant skin cancer of the scalp with skull invasion, dural infiltration and brain involvement is a uncommon lesion. This scenario is most often encountered in patients where initial scalp lesions are not appropriately diagnosed or their extent is underestimated by the patient and/or the doctor. Our study is a retrospective review of 25 patients treated using a multidisciplinary approach (combined plastic surgery/neurosurgery procedure and neuro-oncological management). After a mean follow-up of 7 years, 22 patients did not show local recurrence or distant metastases of their primary disease. Overall, these 22 patients had excellent quality of life; however, three patients died from causes not related to their primary pathology. To obtain a complete and definitive cure, prompt diagnosis of scalp cancers followed by appropriate multidisciplinary management is strongly advised.
头皮恶性皮肤癌伴颅骨侵犯、硬脑膜浸润及脑受累是一种罕见的病变。这种情况最常出现在初始头皮病变未得到正确诊断，或患者和/或医生低估其范围的患者中。我们的研究是对25例采用多学科方法治疗（联合整形手术/神经外科手术及神经肿瘤学管理）的患者进行的回顾性分析。平均随访7年后，22例患者未出现原发性疾病的局部复发或远处转移。总体而言，这22例患者的生活质量良好；然而，3例患者死于与原发性病理无关的原因。为实现彻底根治，强烈建议对头颈部癌症进行及时诊断，随后进行适当的多学科管理。
