Elliott P, Spirito P
The Heart Hospital, London, UK.
Heart. 2008 Oct;94(10):1269-75. doi: 10.1136/hrt.2008.154385. Epub 2008 Jul 24.
In 1958, the British forensic pathologist, Donald Teare, reported a family in which eight young people had died suddenly from asymmetrical hypertrophy of the left ventricle. Five decades on, the prevention of premature death from ventricular tachyarrhythmia, heart failure and stroke remains a major aim of clinical management in what is now called hypertrophic cardiomyopathy. In this paper, we review the underlying mechanisms of death and discuss the strengths and weaknesses of current international guidelines for the identification and treatment of high-risk patients.
1958年，英国法医病理学家唐纳德·蒂尔报告了一个家族，其中8名年轻人因左心室不对称肥厚而突然死亡。五十年过去了，预防因室性心律失常、心力衰竭和中风导致的过早死亡仍然是目前所谓肥厚型心肌病临床管理的主要目标。在本文中，我们回顾了死亡的潜在机制，并讨论了当前国际指南在识别和治疗高危患者方面的优缺点。
