儿童肥厚型心肌病。
Hypertrophic cardiomyopathy in childhood.
机构信息
Department of Cardiology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Heart Fail Clin. 2010 Oct;6(4):433-44, vii-iii. doi: 10.1016/j.hfc.2010.05.004.
Abstract
Hypertrophic cardiomyopathy has important differences in children compared with adults, particularly with regard to the range of causes and the outcomes in infants. Survival is highly dependent on etiology, particularly in the youngest patients, and pursuit of the specific cause is therefore necessary. The clinical utility of defining the genotype in children with familial hypertrophic cardiomyopathy exceeds that at other ages and has a highly favorable cost/benefit ratio. Although most of the available information concerning treatment and prevention of sudden death is derived in adults, management of children requires consideration of the differences in age-specific risk/benefit ratios.
摘要
肥厚型心肌病在儿童中与成人有重要的不同，特别是在病因和婴儿预后方面。生存高度依赖病因，特别是在最小的患者中，因此有必要寻找特定的病因。在家族性肥厚型心肌病患儿中确定基因型的临床意义大于其他年龄段，并且具有非常高的成本效益比。尽管关于治疗和预防猝死的大部分可用信息都来自于成年人，但儿童的管理需要考虑年龄特异性风险/效益比的差异。
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