Kura Naoki, Fujikawa Tetsuya, Tochikubo Osamu
Department of Preventive Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Circ J. 2008 Aug;72(8):1329-35. doi: 10.1253/circj.72.1329.
The aim of the present study was to measure peripheral blood flow (BF) with a new finger-occlusion plethysmograph (FOP) and to compare this to BF measured with a laser Doppler flowmeter (LDF). An additional objective was to investigate the relationship between hypertension-related clinical parameters and peripheral vascular resistance (PVR) estimated from BF and mean blood pressure (BP) (PVR=mean BP/BF) in young subjects.
The present study employed 101 young volunteers (61 males, 40 females, mean age 23.2+/-2.5 years). The FOP was attached to the third finger and an LDF to the fourth fingertip of each subject. BF was measured simultaneously by the 2 devices. A multi-biomedical recorder (TM2425) measured 24-h BP. A high correlation was observed between BF measured by the FOP and LDF (r=0.79, p<0.001). In multiple linear regression analysis, PVR was independently correlated with a family history of hypertension (p<0.01) and with base diastolic BP during sleep (p<0.01), which is a sensitive predictor of severity of hypertension.
Our newly developed FOP can estimate peripheral absolute BF easily. Furthermore, BF determined by the FOP can be used to calculate PVR, and an elevated PVR may be a useful predictor of hypertension.
本研究的目的是使用一种新型手指阻断体积描记仪（FOP）测量外周血流量（BF），并将其与激光多普勒血流仪（LDF）测量的BF进行比较。另一个目的是研究年轻受试者中高血压相关临床参数与根据BF和平均血压（BP）估算的外周血管阻力（PVR）之间的关系（PVR =平均BP/BF）。
本研究招募了101名年轻志愿者（61名男性，40名女性，平均年龄23.2±2.5岁）。将FOP连接到每个受试者的无名指，将LDF连接到其食指指尖。用这两种设备同时测量BF。使用多生物医学记录器（TM2425）测量24小时血压。观察到FOP和LDF测量的BF之间存在高度相关性（r = 0.79，p <0.001）。在多元线性回归分析中，PVR与高血压家族史（p <0.01）以及睡眠期间的基础舒张压（p <0.01）独立相关，基础舒张压是高血压严重程度的敏感预测指标。
我们新开发的FOP能够轻松估算外周绝对BF。此外，由FOP测定的BF可用于计算PVR，PVR升高可能是高血压的一个有用预测指标。
