使用近红外光谱法评估工作记忆和干扰解决过程中前额叶皮层的激活情况。
Activation of the prefrontal cortex in working memory and interference resolution processes assessed with near-infrared spectroscopy.
作者信息
Schreppel Theresa, Egetemeir Johanna, Schecklmann Martin, Plichta Michael M, Pauli Paul, Ellgring Heiner, Fallgatter Andreas J, Herrmann Martin J
机构信息
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
出版信息
Neuropsychobiology. 2008;57(4):188-93. doi: 10.1159/000147473. Epub 2008 Jul 24.
BACKGROUND/AIMS: The present study investigated cortical correlates of top-down processes in visual-object working memory with multi-channel near-infrared spectroscopy.
METHODS
The activity of the prefrontal cortex (PFC) was investigated while performing an n-back task with sequentially presented task-relevant and task-irrelevant faces. The activation patterns in the PFC associated with working memory and interference resolution were examined in 20 healthy adults.
RESULTS
We found a bilateral enhancement of oxygenated haemoglobin in the lateral PFC for remembering relevant faces and in the right lateral PFC for ignoring irrelevant faces. Oxygenation for relevant and irrelevant faces did not differ significantly, indicating that memory processes and interference resolution were interdependent functions, which were subserved by comparable prefrontal regions.
CONCLUSION
This supports the notion that the prefrontal activity during working memory tasks reflects not only maintenance processes but also attentional monitoring and selection processes.
背景/目的：本研究采用多通道近红外光谱技术，探究视觉客体工作记忆中自上而下加工过程的皮层相关性。
方法
在对依次呈现的与任务相关和无关的面孔执行n-back任务时，研究前额叶皮层（PFC）的活动。在20名健康成年人中，检查了与工作记忆和干扰解决相关的PFC激活模式。
结果
我们发现，外侧PFC中氧合血红蛋白在记忆相关面孔时双侧增强，在忽略无关面孔时右侧外侧PFC增强。相关面孔和无关面孔的氧合情况无显著差异，表明记忆过程和干扰解决是相互依存的功能，由相当的前额叶区域提供支持。
结论
这支持了以下观点，即工作记忆任务期间的前额叶活动不仅反映维持过程，还反映注意力监测和选择过程。
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