Venkataraman Suvir, Dirks Robert M, Rothemund Paul W K, Winfree Erik, Pierce Niles A
Nat Nanotechnol. 2007 Aug;2(8):490-4. doi: 10.1038/nnano.2007.225. Epub 2007 Jul 29.
We present a synthetic molecular motor capable of autonomous nanoscale transport in solution. Inspired by bacterial pathogens such as Rickettsia rickettsii, which locomote by inducing the polymerization of the protein actin at their surfaces to form 'comet tails', the motor operates by polymerizing a double-helical DNA tail2. DNA strands are propelled processively at the living end of the growing polymers, demonstrating autonomous locomotion powered by the free energy of DNA hybridization.
我们展示了一种能够在溶液中自主进行纳米级运输的合成分子马达。受诸如立氏立克次体等细菌病原体的启发，这些病原体通过诱导其表面的肌动蛋白聚合形成“彗尾”来移动，该分子马达通过聚合双螺旋DNA尾来运作。DNA链在不断生长的聚合物的活性末端被逐步推进，证明了由DNA杂交自由能驱动的自主运动。
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