Mikula Premysl, Modra Helena, Nemethova Danka, Groch Ladislav, Svobodova Zdenka
Department of Veterinary Public Health and Toxicology, University of Veterinary and Pharmaceutical Sciences, Faculty of Veterinary Hygiene and Ecology, Palackeho 1-3, 612 42 Brno, Czech Republic.
Bull Environ Contam Toxicol. 2008 Nov;81(5):475-9. doi: 10.1007/s00128-008-9500-z. Epub 2008 Jul 25.
The aim of the study was to evaluate subchronic toxic effects of the preparation LASSO MTX (alachlor 42% W/V) on hematological indices and histology of the common carp (Cyprinus carpio L.). In carp exposed for 28 days to LASSO MTX in the concentration of 2,400 microg L(-1), significant differences (p < 0.05), were detected in all indices of the erythrocyte profiles tested except hematocrit (PCV) when compared to controls. At a lower exposure (240 microg L(-1)) concentration of blood hemoglobin and mean corpuscular hemoglobin were significantly reduced. In contrast, no influence of the preparation on leucopoiesis was demonstrated, and only slight changes were observed in histopathological indices.
本研究的目的是评估制剂LASSO MTX（甲草胺42%重量/体积）对鲤鱼（Cyprinus carpio L.）血液学指标和组织学的亚慢性毒性作用。在浓度为2400微克/升的LASSO MTX中暴露28天的鲤鱼，与对照组相比，除血细胞比容（PCV）外，所测试的红细胞谱的所有指标均存在显著差异（p < 0.05）。在较低暴露浓度（240微克/升）下，血液血红蛋白和平均红细胞血红蛋白显著降低。相比之下，未证明该制剂对白细胞生成有影响，且在组织病理学指标中仅观察到轻微变化。
