锌或钛与手性羟基磺酰胺形成的配合物催化苯乙炔对芳香酮的不对称加成反应。
Asymmetric addition of phenylacetylene to aromatic ketones catalyzed by zinc or titanium complexes with chiral hydroxysulfonamide.
作者信息
Zhou Yi-Feng, Han Zhi-Jian, Qiu Li, Liang Jin-Yan, Ren Feng-Bo, Wang Rui
机构信息
College of Life Sciences, China Jiliang University, Hangzhou, China.
出版信息
Chirality. 2009 Apr;21(4):473-9. doi: 10.1002/chir.20622.
PMID:18655167
Abstract
Various new chiral hydroxysulfonamide ligands (3a-3n, 4a-4d) were prepared. Compounds 3a, 3g, 3i, 3k-3n, 4a-4d could accelerate the reaction and reduce reaction time, and 3a, 3g, 3i, 3k-3n catalyzed the reaction without titanium. The results obtained were promising in terms of yields and enantiomeric excesses (3k up to 85% ee, 4a up to 83% ee).
摘要
制备了各种新型手性羟基磺酰胺配体（3a - 3n，4a - 4d）。化合物3a、3g、3i、3k - 3n、4a - 4d可加速反应并缩短反应时间，且3a、3g、3i、3k - 3n在无钛的情况下催化反应。就产率和对映体过量而言，所获得的结果很有前景（3k的对映体过量高达85%，4a的对映体过量高达83%）。
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