From hamartoma to splenic hemangioma.

Vascular benign lesions are the most common non-hematological splenic primary tumors. Although rare they may sometimes pose problems in differential diagnosis, because of their morphologic heterogeneity. We present vascular lesions of the spleen, which were found in archive of the Chair of Pathomorphology. Immunohistochemistry including CD34, CD31, factor VIII, CD8, CD21, CD68, lysosyme, GLUT-1, D2-40, VEGFR3, SMA, Ki67 were performed. 8 benign vascular lesions were identified, including two hamartomas, two lesions representing sclerosing angiomatoid nodular transformation (SANT) and four hemangiomas. We present briefly the spectrum of vascular lesions occurring in the spleen and discuss differential diagnosis and nosological status of selected lesions.