配体门控离子通道的命名法。
A nomenclature for ligand-gated ion channels.
作者信息
Collingridge Graham L, Olsen Richard W, Peters John, Spedding Michael
机构信息
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK.
出版信息
Neuropharmacology. 2009 Jan;56(1):2-5. doi: 10.1016/j.neuropharm.2008.06.063. Epub 2008 Jul 4.
Abstract
The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine3 (5-HT3), gamma-aminobutyric acidA (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors that result from their co-assembly is highly desirable. There is also a need to develop criteria that aid in deciding which of the vast number of heteromeric combinations of subunits that can be assembled in heterologous expression systems in vitro, are known, or likely, to exist as functional receptors in vivo. The aim of this short article is to summarize the progress being made by the nomenclature committee of IUPHAR (NC-IUPHAR) in formulating recommendations that attempt to address these issues.
摘要
参与快速突触传递的配体门控离子通道包括烟碱型乙酰胆碱、5-羟色胺3（5-HT3）、γ-氨基丁酸A（GABA(A)）、甘氨酸、离子型谷氨酸和P2X受体家族。非常需要为构成这些受体的各个亚基以及由它们共同组装而成的受体制定一致且系统的命名法。还需要制定标准，以帮助确定在体外异源表达系统中能够组装的大量亚基异聚体组合中，哪些已知或可能在体内作为功能性受体存在。这篇短文的目的是总结国际药理学联合会命名委员会（NC-IUPHAR）在制定旨在解决这些问题的建议方面所取得的进展。
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