Manengu Chalton, Zhu Chun-Hao, Zhang Guo-Dong, Tian Miao-Miao, Lan Xiao-Bing, Tao Li-Jun, Ma Lin, Liu Yue, Yu Jian-Qiang, Liu Ning
College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, Ningxia Hui Autonomous Region, China.
School of International Education, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China.
Curr Neuropharmacol. 2025;23(3):276-294. doi: 10.2174/1570159X23666241011163035.
Neuropathic pain, a multifaceted and incapacitating disorder, impacts a significant number of individuals globally. Despite thorough investigation, the development of efficacious remedies for neuropathic pain continues to be a formidable task. Recent research has revealed the potential of metabotropic glutamate receptor 5 (mGlu5) as a target for managing neuropathic pain. mGlu5 is a receptor present in the central nervous system that has a vital function in regulating synaptic transmission and the excitability of neurons. This article seeks to investigate the importance of mGlu5 in neuropathic pain pathways, analyze the pharmacological approach of targeting mGlu5 for neuropathic pain treatment, and review the negative allosteric mGlu5 modulators used to target mGlu5. By comprehending the role of mGlu5 in neuropathic pain, we can discover innovative treatment approaches to ease the distress endured by persons afflicted with this incapacitating ailment.
神经性疼痛是一种多方面且使人丧失能力的疾病，在全球影响着大量人群。尽管进行了深入研究，但开发有效的神经性疼痛治疗方法仍然是一项艰巨的任务。最近的研究揭示了代谢型谷氨酸受体5（mGlu5）作为治疗神经性疼痛靶点的潜力。mGlu5是一种存在于中枢神经系统中的受体，在调节突触传递和神经元兴奋性方面具有重要作用。本文旨在探讨mGlu5在神经性疼痛通路中的重要性，分析针对mGlu5治疗神经性疼痛的药理学方法，并综述用于靶向mGlu5的负变构mGlu5调节剂。通过理解mGlu5在神经性疼痛中的作用，我们可以发现创新的治疗方法，以减轻患有这种使人丧失能力疾病的患者所遭受的痛苦。
