Pasquini Massimo, Speca Azzurra, Mastroeni Simona, Delle Chiaie Roberto, Sternberg Cora N, Biondi Massimo
Department of Psychiatric Science and Psychological Medicine, SAPIENZA University of Rome, Rome, Italy.
J Psychosom Res. 2008 Aug;65(2):153-6. doi: 10.1016/j.jpsychores.2008.01.009. Epub 2008 May 21.
The objective of this study is to test the hypothesis that there are differences in the distribution of negative thoughts among major depressive disorders (MDD), depressive disorders among cancer patients, and IFN-alpha-induced depression.
Twenty-three patients affected by MDD, 25 cancer patients affected by depressive disorders (20 MDD), and 19 patients affected by IFN-alpha-induced depression satisfying MDD criteria were evaluated using the 17-item Hamilton Depression Rating Scale and the 13-item Beck Depression Inventory.
Sense of guilt was higher among MDD patients (56.5%) and was lower among cancer patients (4%) (P<.0001). Sense of failure, dissatisfaction, and self-dislike were higher among MDD patients than among IFN-alpha patients (P<.0001).
In our study, patients affected by MDD present a different pattern of symptoms in comparison with patients affected by IFN-alpha-induced depression and depressive disorders. In particular, core depressive thoughts were less frequent in the last two conditions.
本研究的目的是检验以下假设，即重度抑郁症（MDD）、癌症患者的抑郁症以及干扰素-α 诱导的抑郁症患者中消极思维的分布存在差异。
使用17项汉密尔顿抑郁量表和13项贝克抑郁量表对23例重度抑郁症患者、25例患有抑郁症的癌症患者（20例重度抑郁症）以及19例符合重度抑郁症标准的干扰素-α 诱导的抑郁症患者进行评估。
重度抑郁症患者的内疚感较高（56.5%），而癌症患者的内疚感较低（4%）（P<0.0001）。重度抑郁症患者的失败感、不满和自我厌恶感高于干扰素-α 诱导的抑郁症患者（P<0.0001）。
在我们的研究中，与干扰素-α 诱导的抑郁症患者和抑郁症患者相比，重度抑郁症患者呈现出不同的症状模式。特别是，后两种情况下核心抑郁思维的频率较低。
