Smith Kimberley J, Norris Suzanne, McKiernan Susan, Hynes Barbara, O'Dwyer Anne M, O'Mara Shane M
Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland ; Douglas Mental Health University Institute, McGill University, Montreal, Canada.
Hepatology Centre, St. James's Hospital, Dublin, Ireland.
J Clin Exp Hepatol. 2012 Sep;2(3):218-23. doi: 10.1016/j.jceh.2012.03.001. Epub 2012 Sep 21.
The most investigated adverse event associated with interferon-alpha (IFN-α) treatment is depressed mood, with many studies finding a significant increase in depression scale scores from baseline to treatment. This paper is concerned with exploring discrete categories of depressive symptoms (somatic, behavioral, negative cognitions and depressed mood) in order to explore the behavioral syndrome associated with IFN-α.
Thirty-five Hepatitis C patients due to commence IFN-α treatment were assessed using the Structured Clinical Interview (SCID), and the 24-item Hamilton Depression Inventory (HAM-D) at 0 and 8 weeks.
Somatic symptoms comprised the significant majority of scores across all weeks for patients taking IFN-α. Patients who developed a depression had significantly more somatic and mood symptoms at Week 8 than those patients who did not develop a depression.
These exploratory results indicate that the increase in raw depression scores is due to an increase in somatic and mood symptoms, rather than negative cognitions. However, this increase does not correspond to a proportional increase in a particular subscale. These results also indicate that development of an IFN-α-induced depression is due to mood symptoms rather than negative cognitions.
与α干扰素（IFN-α）治疗相关的研究最多的不良事件是情绪低落，许多研究发现从基线到治疗期间抑郁量表评分显著增加。本文旨在探索抑郁症状的不同类别（躯体症状、行为症状、消极认知和情绪低落），以探究与IFN-α相关的行为综合征。
对35名即将开始IFN-α治疗的丙型肝炎患者在第0周和第8周使用结构化临床访谈（SCID）和24项汉密尔顿抑郁量表（HAM-D）进行评估。
在服用IFN-α的患者中，躯体症状在所有周的评分中占绝大多数。在第8周时，出现抑郁的患者比未出现抑郁的患者有更多的躯体和情绪症状。
这些探索性结果表明，原始抑郁评分的增加是由于躯体和情绪症状的增加，而非消极认知。然而，这种增加并不对应于特定子量表的成比例增加。这些结果还表明，IFN-α诱导的抑郁是由情绪症状而非消极认知引起的。
