Nishimori Katsuhiko, Takayanagi Yuki, Yoshida Masahide, Kasahara Yoshiyuki, Young Larry J, Kawamata Masaki
Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan.
Prog Brain Res. 2008;170:79-90. doi: 10.1016/S0079-6123(08)00408-1.
To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr-/-). Oxtr-/- mice had no obvious deficits in fertility or sexual behaviour, but displayed several aberrations in social behaviours, including male aggression, and mother-offspring interaction. In addition, they showed novel physiological defects including obesity, and dysfunction in body temperature control when exposed to cold. We review here our new findings with Oxtr-/- mice, and introduce newly generated Oxtr-Venus knockin mice as a potential tool for examining molecular physiology of Oxtr-neurons.
为了进一步在体内确定催产素受体（OXTR）的功能，我们培育出了Oxtr基因缺失的小鼠（Oxtr-/-）。Oxtr-/-小鼠在生育能力或性行为方面没有明显缺陷，但在社交行为上表现出一些异常，包括雄性攻击性以及母婴互动异常。此外，它们还出现了新的生理缺陷，如肥胖，以及在暴露于寒冷环境时体温调节功能障碍。我们在此回顾关于Oxtr-/-小鼠的新发现，并介绍新培育的Oxtr-Venus基因敲入小鼠，作为研究Oxtr神经元分子生理学的潜在工具。
