Park Su Cheol, Yoon Jung-Hwan, Lee Jeong-Hoon, Yu Su Jong, Myung Sun Jung, Kim Won, Gwak Geum-Youn, Lee Sung-Hee, Lee Soo-Mi, Jang Ja June, Suh Kyung-Suk, Lee Hyo-Suk
Department of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Korea Cancer Center Hospital, Seoul, Republic of Korea.
Cancer Lett. 2008 Nov 28;271(2):314-22. doi: 10.1016/j.canlet.2008.06.019. Epub 2008 Jul 25.
Adrenomedullin is implicated in tumor progression and induced by hypoxia. We evaluated if adrenomedullin signaling is active in hepatocellular carcinoma (HCC), especially under hypoxic conditions, and to analyze its prognostic implication in HCC patients. HCC cells expressed adrenomedullin and its receptor, and hypoxia induced adrenomedullin expression. Adrenomedullin stimulated HCC cell growth via Akt activation, which was prevented by adrenomedullin peptide inhibitor. Clinico-pathological analysis revealed adrenomedullin extent was related to vascular invasion and N-cadherin intensity, which were reported to indicate a poor prognosis. In conclusion, adrenomedullin signaling is hypoxia-inducible and functionally active in HCCs, and its expression may be a prognostic factor.
肾上腺髓质素与肿瘤进展有关，且由缺氧诱导产生。我们评估了肾上腺髓质素信号通路在肝细胞癌（HCC）中是否活跃，特别是在缺氧条件下，并分析其对HCC患者的预后影响。HCC细胞表达肾上腺髓质素及其受体，缺氧诱导肾上腺髓质素表达。肾上腺髓质素通过激活Akt刺激HCC细胞生长，而肾上腺髓质素肽抑制剂可阻止这种激活。临床病理分析显示，肾上腺髓质素的表达程度与血管侵犯和N-钙黏蛋白强度相关，据报道这两者均提示预后不良。总之，肾上腺髓质素信号通路在HCC中是缺氧诱导且功能活跃的，其表达可能是一个预后因素。
