盘基网柄菌发育过程中的振荡信号与网络响应
Oscillatory signaling and network responses during the development of Dictyostelium discoideum.
作者信息
McMains Vanessa C, Liao Xin-Hua, Kimmel Alan R
机构信息
Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892-8028, USA.
出版信息
Ageing Res Rev. 2008 Jul;7(3):234-48. doi: 10.1016/j.arr.2008.04.003. Epub 2008 May 4.
Abstract
Periodic biological variations reflect interactions among molecules and cells, or even organisms. The Dictyostelium cAMP oscillatory circuit is a highly robust example. cAMP oscillations in Dictyostelium arise intracellularly by a complex interplay of activating and inhibiting pathways, are transmitted extracellularly, and synchronize an entire local population. Once established, cAMP signal-relay persists stably for hours. On a two-dimensional surface, >100,000 cells may form a single coordinated territory. In suspension culture, >10(10) cells can oscillate in harmony. This review focuses on molecular mechanisms that cyclically activate and attenuate signal propagation and on chemotactic responses to oscillatory wave progression.
摘要
周期性生物变化反映了分子与细胞甚至生物体之间的相互作用。盘基网柄菌的环磷酸腺苷（cAMP）振荡回路就是一个极具稳健性的例子。盘基网柄菌中的cAMP振荡通过激活和抑制途径的复杂相互作用在细胞内产生，在细胞外进行传递，并使整个局部群体同步化。一旦建立，cAMP信号中继会稳定持续数小时。在二维表面上，超过100,000个细胞可能形成一个单一的协调区域。在悬浮培养中，超过10¹⁰个细胞可以和谐振荡。本综述聚焦于周期性激活和减弱信号传播的分子机制以及对振荡波进展的趋化反应。
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