Vargas F, Andrade J L, Jódar E, Castillo M A, Luna J D, Haro J M
Departamento de Bioquímica, Facultad de Medicina, Universidad de Granada, Spain.
Life Sci. 1991;49(8):611-5. doi: 10.1016/0024-3205(91)90260-i.
Urinary digoxin-like immunoreactive factor (DLIF), arginine-vasopressin (AVP) and other urinary parameters were investigated under normal conditions and after the i.p. injection of the following solutions: distilled water, isotonic and hypertonic NaCl, NaHCO3, KCl and urea, at a rate of 3 ml/100 g body weight. The measurement of digoxin-like immunoreactivity by two different radioimmunoassays showed that DLIF was stimulated by all volume loads regardless of the presence or absence of osmolar compounds. This dissociation between DLIF and urinary sodium excretion suggests that DLIF may not constitute the natriuretic hormone. Moreover, a dissociation between DLIF and AVP excretion also were found, which speaks against the hypothesis of a common mechanism of stimulation for both substances.
在正常条件下以及腹腔注射以下溶液（蒸馏水、等渗和高渗氯化钠、碳酸氢钠、氯化钾和尿素，注射速率为3毫升/100克体重）后，对尿中地高辛样免疫反应因子（DLIF）、精氨酸加压素（AVP）和其他尿液参数进行了研究。通过两种不同的放射免疫测定法对地高辛样免疫反应性进行测量，结果表明，无论是否存在渗透化合物，所有容量负荷均可刺激DLIF。DLIF与尿钠排泄之间的这种分离表明，DLIF可能不构成利钠激素。此外，还发现DLIF与AVP排泄之间存在分离，这与两种物质受共同刺激机制的假设相悖。
