Luecke Richard H, Pearce Bruce A, Wosilait Walter D, Doerge Daniel R, Slikker William, Young John F
Department of Chemical Engineering, University of Missouri-Columbia, Columbia, MO 65231, USA.
Comput Biol Med. 2008 Sep;38(9):962-78. doi: 10.1016/j.compbiomed.2008.06.001. Epub 2008 Jul 26.
A physiologically based pharmacokinetic (PBPK) model and program (called PostNatal) was developed which focuses on postnatal growth. Algorithms defining organ/tissue growth curves from birth through adulthood for male and female humans, dogs, rats, and mice are utilized to calculate the appropriate weight and blood flow for the internal organs/tissues. This Windows based program is actually four linked PBPK models with each PBPK model acting independently or totally integrated with the others through metabolism by first order or Michaelis-Menten kinetics. Data fitting is accomplished by a weighted least square regression algorithm. The model includes linkages for the simulation of pharmacodynamic (PD) effects.
开发了一种基于生理学的药代动力学（PBPK）模型及程序（称为PostNatal），其专注于产后生长。利用定义从出生到成年的男性和女性人类、狗、大鼠及小鼠的器官/组织生长曲线的算法，来计算内部器官/组织的适当重量和血流量。这个基于Windows的程序实际上是四个相互关联的PBPK模型，每个PBPK模型可独立运行，或通过一级动力学或米氏动力学的代谢过程与其他模型完全整合。数据拟合通过加权最小二乘回归算法完成。该模型包括用于模拟药效学（PD）效应的链接。
