银-菲咯啉催化剂催化氨基炔烃的分子内氢胺化反应。

Intramolecular hydroamination of aminoalkynes with silver-phenanthroline catalysts.

作者信息

Carney Jeffrey M, Donoghue Patrick J, Wuest William M, Wiest Olaf, Helquist Paul

机构信息

Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, USA.

出版信息

Org Lett. 2008 Sep 4;10(17):3903-6. doi: 10.1021/ol801458g. Epub 2008 Jul 29.

DOI:10.1021/ol801458g

PMID:18662005

Abstract

Intramolecular hydroamination of several aminoalkynes catalyzed by silver-phenanthroline complexes is reported. This catalyst system complements previous protocols by employing air- and moisture-stable complexes without compromising activity or reaction control. Some of the hydroamination products are subject to a useful aerobic oxidation. Silver-phenanthroline complexes have successfully demonstrated efficacy in the desymmetrization of a prochiral diyne.

摘要

据报道，银 - 菲咯啉配合物催化了几种氨基炔烃的分子内氢胺化反应。该催化体系通过使用对空气和湿气稳定的配合物来补充先前的方法，而不影响活性或反应控制。一些氢胺化产物可进行有用的需氧氧化反应。银 - 菲咯啉配合物已成功证明在手性前体二炔的去对称化反应中具有有效性。