通过苯环胺与炔烃的区域选择性氢胺化和C-H键活化反应催化合成三环喹啉衍生物。
Catalytic synthesis of tricyclic quinoline derivatives from the regioselective hydroamination and C-H bond activation reaction of benzocyclic amines and alkynes.
作者信息
Yi Chae S, Yun Sang Young, Guzei Ilia A
机构信息
Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53201-1881, USA.
出版信息
J Am Chem Soc. 2005 Apr 27;127(16):5782-3. doi: 10.1021/ja042318n.
The cationic ruthenium-hydride complex [(PCy3)2(CO)(CH3CN)2RuH]+BF4- (1) was found to be an effective catalyst for the regioselective coupling reaction of benzocyclic amines and terminal alkynes to form the tricyclic quinoline derivatives. The scope of the reaction was explored by using the catalytic system Ru3(CO)12/NH4PF6. The catalytically active cationic ruthenium-acetylide complex [(PCy3)2(CO)(CH3CN)2RuCCPh]+BF4- was isolated from the reaction of 1 with phenylacetylene.
发现阳离子氢化钌配合物[(PCy3)2(CO)(CH3CN)2RuH]+BF4-（1）是用于苯环胺与末端炔烃区域选择性偶联反应以形成三环喹啉衍生物的有效催化剂。通过使用催化体系Ru3(CO)12/NH4PF6探索了该反应的适用范围。从1与苯乙炔的反应中分离出了具有催化活性的阳离子钌乙炔配合物[(PCy3)2(CO)(CH3CN)2RuCCPh]+BF4-。
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