Mori Yasukiyo, Kosaki Atsushi, Kishimoto Noriko, Kimura Tatsuji, Iida Kumiko, Fukui Masayoshi, Nakajima Fumitaka, Nagahara Masayuki, Urakami Masaya, Iwasaka Toshiji, Matsubara Hiroaki
Department of Medicine, Division of Cardiology and Nephrology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
Am J Nephrol. 2009;29(1):18-24. doi: 10.1159/000148646. Epub 2008 Jul 26.
S100A12, also known as EN-RAGE (extracellular newly identified receptor for advanced glycation end products binding protein) is a ligand for RAGE, and has been proposed to contribute to the development of atherosclerosis. In this study, we examined the plasma S100A12 concentration in patients with ESRD and undergoing hemodialysis (HD) and evaluated the relation between S100A12 level and carotid intimal media thickness (IMT) by ultrasound.
We measured plasma S100A12 concentration in 72 HD patients and 42 control subjects. IMT of the carotid artery was measured by high-resolution B-mode ultrasonography in 46 HD patients.
The mean plasma S100A12 level was 2.3-fold higher in HD patients than in control subjects (25.0 +/- 2.32 vs. 10.7 +/- 0.97 ng/ml, p < 0.001). Stepwise multiple regression analysis identified circulating white blood cell count as a positive independent determinant and total cholesterol and serum albumin levels as negative independent determinants of plasma S100A12 concentration. The maximum IMT was positively correlated with plasma S100A12 level. Stepwise multiple regression analysis also identified plasma S100A12 as a significant independent determinant of the maximum IMT.
These findings suggest that S100A12 protein is involved in the acceleration of atherosclerosis in HD patients.
S100A12，也被称为EN-RAGE（细胞外新鉴定的晚期糖基化终产物结合蛋白受体），是RAGE的一种配体，并且被认为与动脉粥样硬化的发展有关。在本研究中，我们检测了终末期肾病（ESRD）且正在接受血液透析（HD）患者的血浆S100A12浓度，并通过超声评估了S100A12水平与颈动脉内膜中层厚度（IMT）之间的关系。
我们测量了72例HD患者和42例对照者的血浆S100A12浓度。46例HD患者通过高分辨率B型超声测量颈动脉IMT。
HD患者的血浆S100A12平均水平比对照者高2.3倍（25.0±2.32对10.7±0.97 ng/ml，p<0.001）。逐步多元回归分析确定循环白细胞计数是血浆S100A12浓度的正独立决定因素，总胆固醇和血清白蛋白水平是负独立决定因素。最大IMT与血浆S100A12水平呈正相关。逐步多元回归分析还确定血浆S100A12是最大IMT的重要独立决定因素。
这些发现表明S100A12蛋白参与了HD患者动脉粥样硬化的加速过程。
