AGEs 受体的分子特征及小分子抑制剂的研究进展。
Molecular Characteristics of RAGE and Advances in Small-Molecule Inhibitors.
机构信息
Department of Molecular Biology, College of Natural Sciences, Pusan National University, Jangjeon-dong, Geumjeong-gu, Busan 46241, Korea.
Insitute for Plastic Information and Energy Materials and Sustainable Utilization of Photovoltaic Energy Research Center, Pusan National University, Jangjeon-dong, Geumjeong-gu, Busan 46241, Korea.
出版信息
Int J Mol Sci. 2021 Jun 27;22(13):6904. doi: 10.3390/ijms22136904.
Receptor for advanced glycation end-products (RAGE) is a member of the immunoglobulin superfamily. RAGE binds and mediates cellular responses to a range of DAMPs (damage-associated molecular pattern molecules), such as AGEs, HMGB1, and S100/calgranulins, and as an innate immune sensor, can recognize microbial PAMPs (pathogen-associated molecular pattern molecules), including bacterial LPS, bacterial DNA, and viral and parasitic proteins. RAGE and its ligands stimulate the activations of diverse pathways, such as p38MAPK, ERK1/2, Cdc42/Rac, and JNK, and trigger cascades of diverse signaling events that are involved in a wide spectrum of diseases, including diabetes mellitus, inflammatory, vascular and neurodegenerative diseases, atherothrombosis, and cancer. Thus, the targeted inhibition of RAGE or its ligands is considered an important strategy for the treatment of cancer and chronic inflammatory diseases.
晚期糖基化终产物受体（RAGE）是免疫球蛋白超家族的成员。RAGE 结合并介导细胞对一系列 DAMPs（损伤相关分子模式分子）的反应，如 AGEs、HMGB1 和 S100/钙粒蛋白，作为先天免疫传感器，能够识别微生物 PAMPs（病原体相关分子模式分子），包括细菌 LPS、细菌 DNA 以及病毒和寄生虫蛋白。RAGE 及其配体刺激多种途径的激活，如 p38MAPK、ERK1/2、Cdc42/Rac 和 JNK，并引发涉及广泛疾病的多种信号事件级联反应，包括糖尿病、炎症、血管和神经退行性疾病、动脉粥样硬化和癌症。因此，靶向抑制 RAGE 或其配体被认为是治疗癌症和慢性炎症性疾病的重要策略。
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