益气散聚方对非酒精性脂肪性肝病的影响：一项随机对照试验

[Effects of Yiqi Sanju Formula on non-alcoholic fatty liver disease: a randomized controlled trial].

作者信息

Lou Shao-ying, Liu Yi, Ma Yu-ying, Chen Hai-ying, Chen Wei-hua, Ying Jian, He Yan-ming, Wang Wen-jian

机构信息

Institution of Chinese Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.

出版信息

Zhong Xi Yi Jie He Xue Bao. 2008 Aug;6(8):793-8. doi: 10.3736/jcim20080805.

DOI:10.3736/jcim20080805

PMID:18664346

Abstract

OBJECTIVE

To observe the therapeutic effects of Yiqi Sanju Formula (YQSJF), a compound traditional Chinese herbal medicine, in treatment of non-alcoholic fatty liver disease (NAFLD).

METHODS

Sixty-seven patients diagnosed with NAFLD were randomly divided into two groups: YQSJF-treated group (39 cases) and placebo group (28 cases). The NAFLD patients in the two groups were treated with YQSJF and placebo respectively for 3 months. Clinical symptoms, the CT ratio of liver-spleen, body mass index (BMI), waist circumference, homeostatic model assessment for insulin resistance (HOMA2-IR) and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-alpha (TNF-alpha), high sensitivity C-reactive protein (hs-CRP), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were evaluated before and after treatment.

RESULTS

After treatment, the clinical symptoms were improved and the levels of BMI, waist circumference, HOMA2-IR, ALT, AST, TG and TC were decreased significantly in the YQSJF-treated group (P<0.05). The CT ratio of liver-spleen in the YQSJF-treated group was increased significantly as compared with the placebo group (P<0.01).

摘要

目的

观察复方中药益气散聚方（YQSJF）治疗非酒精性脂肪性肝病（NAFLD）的疗效。

方法

将67例确诊为NAFLD的患者随机分为两组：益气散聚方治疗组（39例）和安慰剂组（28例）。两组NAFLD患者分别给予益气散聚方和安慰剂治疗3个月。治疗前后评估临床症状、肝脏脾脏CT比值、体重指数（BMI）、腰围、胰岛素抵抗稳态模型评估（HOMA2-IR）以及丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、肿瘤坏死因子-α（TNF-α）、高敏C反应蛋白（hs-CRP）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）水平。