Dahlöf C, Dahlof P, Lundberg J M, Strömbom U
Department of Clinical Pharmacology, Sahlgren's Hospital, Gothenburg University, Sweden.
Pulm Pharmacol. 1988;1(1):3-6. doi: 10.1016/0952-0600(88)90003-8.
Twenty-five elderly asthmatic patients attending the internal medicine emergency ward because of an acute exacerbation of asthma were sampled, prior to acute treatment, for determination of systemic venous plasma levels of noradrenaline (NA), adrenaline (A) and neuropeptide Y-like immunoreactivity (NPY-LI). Whereas NA and NPY-LI were about two-fold higher than control values, plasma A levels were not significantly increased. Twelve of the asthmatic patients were also tested at resting stable conditions and were essentially asymptomatic. All values were then similar to those of control subjects (n = 28) except for a significantly higher NPY-LI plasma level in asthmatics. In seven of these patients a near maximal physical exercise test caused significantly increased NA, A and NPY-LI plasma levels. It is concluded that the acute asthma attack is associated with elevated NA and NPY-LI plasma levels, but an impaired A response. Furthermore, that circulating NPY under these conditions has a nervous rather than adrenal origin.
选取了25名因哮喘急性加重而入住内科急诊病房的老年哮喘患者，在进行急性治疗前，测定其全身静脉血浆中去甲肾上腺素（NA）、肾上腺素（A）和神经肽Y样免疫反应性（NPY-LI）的水平。NA和NPY-LI水平约为对照值的两倍，而血浆A水平未显著升高。12名哮喘患者在静息稳定状态下也进行了检测，基本无症状。除哮喘患者的NPY-LI血浆水平显著较高外，所有值均与对照受试者（n = 28）相似。在其中7名患者中，接近最大运动量的运动试验导致NA、A和NPY-LI血浆水平显著升高。结论是，急性哮喘发作与NA和NPY-LI血浆水平升高有关，但A反应受损。此外，在这些情况下，循环中的NPY起源于神经而非肾上腺。
