Stead Jennifer, Headley Catherine, Ioffreda Michael, Kovarik Carrie, Werth Victoria
Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.
J Clin Rheumatol. 2008 Dec;14(6):338-41. doi: 10.1097/RHU.0b013e31817d1183.
Tumid lupus erythematosus (LE) is a rare variant of chronic cutaneous LE that is characterized clinically by smooth, nonscarring, pink to violaceous papules or plaques without evidence of surface change. Histopathologic features include superficial and deep lymphocytic infiltration in a perivascular and periadnexal distribution, with dermal interstitial mucin deposition and focal or absent dermoepidermal junction involvement. These clinical and histopathologic features can be challenging to differentiate from other cutaneous diseases. This is particularly true because patients with tumid LE usually do not have other manifestations of systemic LE or cutaneous LE. We present 2 cases of tumid LE, one associated with concomitant systemic LE and the other occurring concurrently with discoid LE. Furthermore, we demonstrate the rare occurrence of a patient with tumid LE occurring below the waist at a photo-protected site.
肿胀性红斑狼疮（LE）是慢性皮肤型LE的一种罕见变异型，临床特征为光滑、无瘢痕、粉红色至紫罗兰色丘疹或斑块，无表面改变迹象。组织病理学特征包括血管周围和附属器周围分布的浅层和深层淋巴细胞浸润，伴有真皮间质黏蛋白沉积以及局灶性或无真皮表皮交界处受累。这些临床和组织病理学特征可能难以与其他皮肤疾病相鉴别。尤其如此的是，肿胀性LE患者通常没有系统性LE或皮肤型LE的其他表现。我们报告2例肿胀性LE，1例伴有系统性LE，另1例与盘状LE同时发生。此外，我们展示了1例肿胀性LE患者在腰部以下光保护部位发病的罕见情况。
