Ruiz H, Sánchez J L
University of Puerto Rico, School of Medicine, Department of Dermatology, San Juan 00936-5067, USA.
Am J Dermatopathol. 1999 Aug;21(4):356-60. doi: 10.1097/00000372-199908000-00008.
Tumid lupus erythematosus (TLE) is a subtype of discoid lupus erythematosus (DLE) whose clinical characteristics rarely have been described in the literature.
To describe the clinical, histopathologic, and other laboratory findings in tumid lupus erythematosus.
Clinical and laboratory findings were reviewed in four patients who had been diagnosed with tumid lupus erythematosus by conventional microscopy. The diagnoses were characterized by a superficial and deep perivascular infiltrate of lymphocytes and deposits of mucin in foci in the reticular dermis.
All four patients were young women. Ages ranged from 16 to 39 years (mean 21 years). The lesions consisted of numerous erythematous papules and plaques, some with annular configuration situated in the face and neck, trunk, and upper extremities. All four patients had concurrent lesions of classic DLE, three of them had systemic lupus erythematosus (SLE). Direct immunofluorescence test results were negative in nonexposed lesional skin of two of the patients.
The clinical findings of concurrent lesions of TLE and classic DLE in the same patient, the presence of lesions of TLE in patients with SLE, and the histologic findings demonstrate that TLE is a distinct manifestation of DLE, and as such, a cutaneous expression of SLE.
肿胀性红斑狼疮（TLE）是盘状红斑狼疮（DLE）的一种亚型，其临床特征在文献中鲜有描述。
描述肿胀性红斑狼疮的临床、组织病理学及其他实验室检查结果。
回顾了4例经传统显微镜诊断为肿胀性红斑狼疮患者的临床和实验室检查结果。诊断特征为淋巴细胞在浅层和深层血管周围浸润以及网状真皮灶性黏蛋白沉积。
所有4例患者均为年轻女性。年龄范围为16至39岁（平均21岁）。皮损由众多红斑丘疹和斑块组成，部分呈环状，位于面部、颈部、躯干及上肢。所有4例患者均合并有典型DLE皮损，其中3例患有系统性红斑狼疮（SLE）。2例患者非暴露部位皮损的直接免疫荧光试验结果为阴性。
同一患者同时存在TLE和典型DLE皮损、SLE患者出现TLE皮损以及组织学检查结果均表明，TLE是DLE的一种独特表现形式，因此也是SLE的一种皮肤表现。
