Sileikiene Vaida, Mosenthin Rainer, Bauer Eva, Piepho Hans-Peter, Tafaj Myqerem, Kruszewska Danuta, Weström Björn, Erlanson-Albertsson Charlotte, Pierzynowski Stefan G
Institute of Animal Nutrition and daggerBioinformatics Unit, University of Hohenheim, Stuttgart, Germany.
Pancreas. 2008 Aug;37(2):196-202. doi: 10.1097/MPA.0b013e31816386f4.
Nutrients passing the ileum induce mechanisms regulating pancreatic secretion, but the effect of short-chain fatty acids (SCFAs) present in the ileum because of either intestinal fermentation or due to the cecoileal reflux is still unclear. This study investigated the effect of ileal SCFAs on pancreatic secretion and plasma levels of peptide YY, cholecystokinin, motilin, and neurotensin.
The pigs were fitted with pancreatic duct, ileal, and jugular vein catheters, and a duodenal T-shaped cannula. Saline, 85.0 or 170.0 mM acetate, 5.0 or 10.0 mM butyrate, 7.5 or 15.0 mM propionate were infused into the ileum during feeding.
The ileal infusions of SCFAs did not affect the pancreatic juice outflow and the lipase output. The protein output was lower when 10.0 mM butyrate or 170.0 mM acetate were infused. The trypsin output decreased for most of the SCFA infusions. The alpha-amylase output decreased for the infusion of 10.0 mM butyrate and tended to decrease for 170.0 mM acetate. The infusions did not change gut hormone level.
Ileal SCFAs might induce an inhibition of pancreatic enzyme secretion under prandial conditions. Ileal SCFAs do not inhibit pancreatic secretion by a hormonal pathway involving the release of peptide YY, motilin, neurotensin, or cholecystokinin.
通过回肠的营养物质可诱导调节胰腺分泌的机制，但因肠道发酵或盲肠回肠反流而存在于回肠中的短链脂肪酸（SCFAs）的作用仍不清楚。本研究调查了回肠SCFAs对胰腺分泌以及肽YY、胆囊收缩素、胃动素和神经降压素血浆水平的影响。
给猪安装胰管、回肠和颈静脉导管以及十二指肠T形套管。在喂食期间将生理盐水、85.0或170.0 mM乙酸盐、5.0或10.0 mM丁酸盐、7.5或15.0 mM丙酸盐注入回肠。
回肠注入SCFAs不影响胰液流出和脂肪酶输出。注入10.0 mM丁酸盐或170.0 mM乙酸盐时蛋白质输出较低。大多数SCFAs注入时胰蛋白酶输出减少。注入10.0 mM丁酸盐时α-淀粉酶输出减少，注入170.0 mM乙酸盐时α-淀粉酶输出有减少趋势。注入未改变肠道激素水平。
回肠SCFAs可能在进食状态下诱导胰腺酶分泌受到抑制。回肠SCFAs不会通过涉及肽YY、胃动素、神经降压素或胆囊收缩素释放的激素途径抑制胰腺分泌。
