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WNT signalling is both an inducer and effector of glucagon-like peptide-1.

作者信息

Gustafson B, Smith U

机构信息

The Lundberg Laboratory for Diabetes Research, Center of Excellence for Metabolic and Cardiovascular Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

出版信息

Diabetologia. 2008 Oct;51(10):1768-70. doi: 10.1007/s00125-008-1109-6. Epub 2008 Jul 30.

DOI:10.1007/s00125-008-1109-6
PMID:18665346
Abstract
摘要

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本文引用的文献

1
The WNT signalling pathway and diabetes mellitus.WNT信号通路与糖尿病
Diabetologia. 2008 Oct;51(10):1771-80. doi: 10.1007/s00125-008-1084-y. Epub 2008 Aug 12.
2
Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation.胰高血糖素样肽-1激活依赖TCF7L2的Wnt信号通路可增强胰腺β细胞增殖。
J Biol Chem. 2008 Mar 28;283(13):8723-35. doi: 10.1074/jbc.M706105200. Epub 2008 Jan 23.
3
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.
炎症与代谢性疾病相遇：由胰高血糖素样肽-1介导的直觉感受
Front Immunol. 2016 Apr 22;7:154. doi: 10.3389/fimmu.2016.00154. eCollection 2016.
4
Glucagon-like peptide-1(GLP-1) receptor agonists: potential to reduce fracture risk in diabetic patients?胰高血糖素样肽-1（GLP-1）受体激动剂：降低糖尿病患者骨折风险的潜力？
Br J Clin Pharmacol. 2016 Jan;81(1):78-88. doi: 10.1111/bcp.12777.
5
The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective.Wnt 信号通路和 TCF7L2 在糖尿病中的作用：目前的认识、争议和展望。
Cell Biosci. 2012 Aug 14;2(1):28. doi: 10.1186/2045-3701-2-28.
6
The Incretins and Pancreatic beta-Cells: Use of Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide to Cure Type 2 Diabetes Mellitus.肠促胰岛素与胰腺β细胞：利用胰高血糖素样肽-1和葡萄糖依赖性促胰岛素多肽治疗2型糖尿病
Korean Diabetes J. 2010 Feb;34(1):2-9. doi: 10.4093/kdj.2010.34.1.2. Epub 2010 Feb 28.
7
WNT/beta-catenin increases the production of incretins by entero-endocrine cells.WNT/β-连环蛋白增加肠内分泌细胞分泌肠促胰岛素。
Diabetologia. 2009 Sep;52(9):1913-24. doi: 10.1007/s00125-009-1429-1. Epub 2009 Jul 7.
TCF7L2基因常见变异增加2型糖尿病风险的机制。
J Clin Invest. 2007 Aug;117(8):2155-63. doi: 10.1172/JCI30706.
4
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.转录因子7样蛋白2（TCF7L2）基因多态性携带者中胰高血糖素样肽-1诱导的胰岛素分泌受损。
Diabetologia. 2007 Dec;50(12):2443-50. doi: 10.1007/s00125-007-0753-6. Epub 2007 Jul 28.
5
Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?2型糖尿病中肠促胰岛素效应降低：是糖尿病状态的原因还是结果？
Diabetes. 2007 Aug;56(8):1951-9. doi: 10.2337/db07-0100. Epub 2007 May 18.
6
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.转录因子7样蛋白2（TCF7L2）基因变体赋予2型糖尿病风险。
Nat Genet. 2006 Mar;38(3):320-3. doi: 10.1038/ng1732. Epub 2006 Jan 15.
7
Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells.锂和β-连环蛋白对肠道内分泌L细胞中胰高血糖素原基因的转录激活作用。
J Biol Chem. 2003 Jan 10;278(2):1380-7. doi: 10.1074/jbc.M206006200. Epub 2002 Nov 5.