Young E J
Section of Infectious Diseases, Veterans Affairs Medical Center, Houston, Texas 77030.
Rev Infect Dis. 1991 May-Jun;13(3):359-72. doi: 10.1093/clinids/13.3.359.
The serum agglutination test (SAT) and 2-mercaptoethanol (2ME) agglutination were used in studies of the sera of 214 patients in whom brucellosis was suspected. On the basis of historical, epidemiologic, clinical, and serologic data, four groups were identified: group I (108 cases) had negative agglutination reactions, and brucellosis was considered unlikely; group II (57 cases) had positive agglutination reactions, and active brucellosis was diagnosed; group III (37 cases) had positive agglutination reactions, but other factors--notably, a history of prior infection--made inactive brucellosis likely; and group IV (12 cases) had positive agglutination reactions, but insufficient data were available for further classification. Most patients with active brucellosis had agglutinin titers of greater than or equal to 160; however, no single titer was always diagnostic. Although more sensitive tests are available, agglutination reactions provide data sufficient to differentiate active from inactive disease when other factors are considered and follow-up sera are tested. This article discusses individual cases and reviews the literature on the diagnosis of brucellosis.
血清凝集试验（SAT）和2-巯基乙醇（2ME）凝集试验被用于对214例疑似布鲁氏菌病患者的血清研究。根据病史、流行病学、临床和血清学数据，将患者分为四组：第一组（108例）凝集反应阴性，布鲁氏菌病可能性不大；第二组（57例）凝集反应阳性，确诊为活动性布鲁氏菌病；第三组（37例）凝集反应阳性，但其他因素——尤其是既往感染史——提示可能为非活动性布鲁氏菌病；第四组（12例）凝集反应阳性，但缺乏进一步分类的足够数据。大多数活动性布鲁氏菌病患者的凝集素滴度大于或等于160；然而，没有单一滴度总能确诊。尽管有更敏感的检测方法，但当考虑其他因素并检测随访血清时，凝集反应提供的数据足以区分活动性疾病和非活动性疾病。本文讨论了个别病例并回顾了布鲁氏菌病诊断的相关文献。
