Schubert Stephan, Schmitz Thomas, Weiss Markus, Nagdyman Nicole, Huebler Michael, Alexi-Meskishvili Vladimir, Berger Felix, Stiller Brigitte
Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
J Clin Monit Comput. 2008 Aug;22(4):299-307. doi: 10.1007/s10877-008-9133-0. Epub 2008 Jul 30.
Continuous and non-invasive measurement of cardiac output (CO) may contribute helpful information to the care and treatment of the critically ill pediatric patient. Different methods are available but their clinical verification is still a major problem.
Comparison of reliability and safety of two continuous non-invasive methods with transthoracic echocardiography (TTE) for CO measurement: electric velocimetry technique (EV, Aesculon) and transesophageal Doppler (TED, CardioQP). METHODS/MATERIAL: In 26 infants and children who had undergone corrective cardiac surgery at a median age of 3.5 (1-17) years CO and stroke volume (SV) were obtained by EV, TED and TTE. Each patient had five measurements on the first day after surgery, during mechanical ventilation and sedation.
Values for CO and SV from TED and EV correlated well with those of TTE (r = 0.85 and r = 0.88), but mean values were significantly lower than the values of TTE for TED (P = 0.02) and EV (P = 0.001). According to Bland-Altman analysis, bias was 0.36 l/min with a precision of 1.67 l/min for TED vs. TTE and 0.87 l/min (bias) with a precision of 3.26 l/min for EV vs. TTE. No severe adverse events were observed and the handling of both systems was easy in the sedated child.
In pediatric patients non-invasive measurement of CO and SV with TED and EV is useful for continuous monitoring after heart surgery. Both new methods seem to underestimate cardiac output in terms of absolute values. However, TED shows tolerable bias and precision and may be helpful for continuous CO monitoring in a deeply sedated and ventilated pediatric patient, e.g. in the operating room or intensive care unit.
连续无创测量心输出量(CO)可为危重症儿科患者的护理和治疗提供有用信息。有多种不同方法可用,但它们的临床验证仍是一个主要问题。
比较两种连续无创测量CO的方法(电测速技术(EV,Aesculon)和经食管多普勒(TED,CardioQP))与经胸超声心动图(TTE)测量CO的可靠性和安全性。
方法/材料:对26例年龄中位数为3.5(1 - 17)岁的接受心脏矫正手术的婴幼儿和儿童,通过EV、TED和TTE测量CO和每搏输出量(SV)。每位患者在术后第一天机械通气和镇静期间进行五次测量。
TED和EV测得的CO和SV值与TTE测得的值相关性良好(r分别为0.85和0.88),但TED(P = 0.02)和EV(P = 0.001)的平均值显著低于TTE测得的值。根据Bland - Altman分析,TED与TTE相比偏差为0.36 l/min,精密度为1.67 l/min;EV与TTE相比偏差为0.87 l/min,精密度为3.26 l/min。未观察到严重不良事件,且在镇静儿童中这两种系统操作都很简便。
在儿科患者中,使用TED和EV无创测量CO和SV对心脏手术后的连续监测有用。就绝对值而言,这两种新方法似乎都低估了心输出量。然而,TED显示出可接受的偏差和精密度,可能有助于在深度镇静和通气的儿科患者(如手术室或重症监护病房)中进行连续CO监测。