室温下ICl诱导的1-酰基-5-羟基-4,5-二氢-1H-吡唑的脱水/碘化反应：合成取代的1-酰基-4-碘-1H-吡唑的一条选择性途径。
Room temperature ICl-induced dehydration/iodination of 1-acyl-5-hydroxy-4,5-dihydro-1H-pyrazoles. a selective route to substituted 1-acyl-4-iodo-1H-pyrazoles.
作者信息
Waldo Jesse P, Mehta Saurabh, Larock Richard C
机构信息
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
出版信息
J Org Chem. 2008 Sep 5;73(17):6666-70. doi: 10.1021/jo800789p. Epub 2008 Jul 30.
Abstract
A number of new functionally substituted 1-acyl-5-hydroxy-4,5-dihydro-1H-pyrazoles have been prepared in moderate to excellent yields from the corresponding 2-alkyn-1-ones. The resulting dihydropyrazoles undergo dehydration and iodination in the presence of ICl and Li2CO3 at room temperature to provide 1-acyl-4-iodo-1H-pyrazoles.
摘要
已从相应的2-炔-1-酮以中等至优异的产率制备了多种新型功能取代的1-酰基-5-羟基-4,5-二氢-1H-吡唑。所得的二氢吡唑在室温下于ICl和Li2CO3存在下进行脱水和碘化反应，以提供1-酰基-4-碘-1H-吡唑。
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Room temperature ICl-induced dehydration/iodination of 1-acyl-5-hydroxy-4,5-dihydro-1H-pyrazoles. a selective route to substituted 1-acyl-4-iodo-1H-pyrazoles.室温下ICl诱导的1-酰基-5-羟基-4,5-二氢-1H-吡唑的脱水/碘化反应：合成取代的1-酰基-4-碘-1H-吡唑的一条选择性途径。
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