Palomera L, García Díez I, Martínez García R
Servicio de Hematología-Hemoterapia, Hospital General Básico, Cabra, Córdoba.
Sangre (Barc). 1991 Apr;36(2):135-9.
The recent introduction of new methods to identify different lymphocytic subsets has made it possible to recognise a rare variant of the classic hairy cell leukaemia, showing intermediate features between prolymphocytic leukaemia and hairy cell leukaemia. A 37-year-old patient is reported who followed a mildly aggressive clinical course and had massive splenomegaly without lymph node enlargement. Moderate leucopenia with lymphocytosis was present, with frequent hairy cells carrying one prominent nucleole. The cytochemical pattern include tartrate-sensitive acid phosphatase positivity, and the immunophenotype of such cells was CD22++, CD11++, CD24-, CD25-, CD2-, CD5-, CD19++. No lamellar ribosomal complex was seen in the ultrastructural study of the hairy cells. The patient was diagnosed as having variant hairy cell leukaemia and achieved partial response after splenectomy. The clinical, diagnostic and therapeutic aspects of this rare variant are discussed.
最近引入的识别不同淋巴细胞亚群的新方法，使得识别经典毛细胞白血病的一种罕见变异型成为可能，该变异型表现出原淋巴细胞白血病和毛细胞白血病之间的中间特征。本文报道了一名37岁的患者，其临床病程呈轻度侵袭性，有巨大脾肿大但无淋巴结肿大。存在中度白细胞减少伴淋巴细胞增多，常见的毛细胞带有一个明显的核仁。细胞化学模式包括对酒石酸敏感的酸性磷酸酶阳性，此类细胞的免疫表型为CD22++、CD11++、CD24-、CD25-、CD2-、CD5-、CD19++。在毛细胞的超微结构研究中未见板层核糖体复合物。该患者被诊断为变异型毛细胞白血病，脾切除术后获得部分缓解。本文讨论了这种罕见变异型的临床、诊断和治疗方面。
