Davis Cindy D, Ross Sharon A
Nutritional Science Research Group, National Cancer Institute, 6130 Executive Blvd, Suite 3160, Rockville, MD 20892-7328, USA.
Nutr Rev. 2008 Aug;66(8):477-82. doi: 10.1111/j.1753-4887.2008.00080.x.
MicroRNAs (miRNAs) are an abundant class of short noncoding RNAs that are widely expressed in mammalian cells and are important in post-translational gene regulation, including regulation of cell proliferation, apoptosis, and differentiation processes. miRNAs are involved in cancer initiation and progression and their expression patterns serve as phenotypic signatures of different cancers. Recent evidence suggests that dietary components as diverse as folate, retinoids, and curcumin exert cancer-protective effects through modulation of miRNA expression. miRNAs may be useful as biomarkers of cancer prevention or nutritional status, as well as serve as potential molecular targets that are influenced by dietary interventions.
微小RNA（miRNA）是一类丰富的短链非编码RNA，在哺乳动物细胞中广泛表达，在翻译后基因调控中发挥重要作用，包括对细胞增殖、凋亡和分化过程的调控。miRNA参与癌症的发生和发展，其表达模式可作为不同癌症的表型特征。最近的证据表明，叶酸、视黄醇和姜黄素等多种饮食成分可通过调节miRNA表达发挥癌症保护作用。miRNA可能作为癌症预防或营养状况的生物标志物，也可能作为受饮食干预影响的潜在分子靶点。
