BGI-Shenzhen, Shenzhen, 518083, China.
China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China.
Mol Neurobiol. 2022 Nov;59(11):6790-6804. doi: 10.1007/s12035-022-03012-0. Epub 2022 Aug 30.
Numerous studies have investigated the risk factors of Alzheimer's disease (AD); however, AD-risk factors related miRNAs were rarely reported. In this study, AD-risk factor related miRNAs of 105 Chinese individuals (45 AD patients and 60 cognitively normal controls) were investigated. The results showed that Hsa-miR-185-5p, Hsa-miR-20a-5p, and Hsa-miR-497-5p were related to AD and education, Hsa-miR-185-5p, Hsa-miR-181c-5p, Hsa-miR-664a-3p, Hsa-miR-27a-3p, Hsa-miR-451a, and Hsa-miR-320a were related to AD and depression. Target prediction of above miRNAs showed that these miRNAs were involved in the generation and clearance of amyloid-beta (Aβ), important molecules related to cognition, and disease-activated microglia response to AD. It is worth noting that Hsa-miR-185-5p was related to both education and depression, whose decreased expression pattern in AD patients was alleviated by education and enhanced by depression, and participates in Aβ generation and accumulation. Our results indicated that certain education and depression factors can contribute to AD progression by modulating miRNA expression, implying that preventive interventions might alter AD progression in Chinese patients.
许多研究都探讨了阿尔茨海默病（AD）的危险因素；然而，与 AD 风险因素相关的 microRNA 很少有报道。在这项研究中，我们调查了 105 名中国个体（45 名 AD 患者和 60 名认知正常对照者）的 AD 风险因素相关 microRNA。结果表明，Hsa-miR-185-5p、Hsa-miR-20a-5p 和 Hsa-miR-497-5p 与 AD 和教育有关，Hsa-miR-185-5p、Hsa-miR-181c-5p、Hsa-miR-664a-3p、Hsa-miR-27a-3p、Hsa-miR-451a 和 Hsa-miR-320a 与 AD 和抑郁有关。上述 microRNA 的靶预测表明，这些 microRNA 参与了淀粉样蛋白-β（Aβ）的产生和清除，与认知有关的重要分子，以及疾病激活的小胶质细胞对 AD 的反应。值得注意的是，Hsa-miR-185-5p 与教育和抑郁都有关，其在 AD 患者中的表达模式减少可通过教育缓解，而可通过抑郁增强，并且参与 Aβ的产生和积累。我们的结果表明，某些教育和抑郁因素可通过调节 microRNA 表达来促进 AD 的进展，这表明预防干预可能会改变中国患者的 AD 进展。
